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On December 28, 1967, the legalized contraception in France, including the pill.

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Do endocrine treatments for breast cancer have a negative impact on lipid profiles and cardiovascular risk in postmenopausal women?

COCs should not be used during pregnancy to treat threatened or habitual abortion.

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Several factors play a role in determining which side effects are likely (or unlikely) to occur, including the strength of the estrogen, the type of progestin, and the dose of progestin.

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Large doses of estrogen (5 mg conjugated estrogens per day), comparable to those used to treat cancer of the prostate and breast, have been shown in a large prospective clinical trial in men to increase the risks of nonfatal myocardial infarction, pulmonary embolism, and thrombophlebitis.

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However, in December 2003, a review of the available evidence on the risks and benefits of HRT by the Medicines and Healthcare products Regulatory Agency (MHRA) and the Committee on Safety of Medicines (CSM) in the UK, concluded that the risks of using HRT long-term to prevent osteoporosis in women aged over 50 years exceed the benefits.

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Used in the past for prevention of postpartum breast engorgement; FDA has withdrawn approval of estrogen-containing drugs for this indication, since estrogens have not been shown to be safe for this use.

We also examined the risk of coronary disease according to the current dose of oral conjugated estrogen ( Table 4 Relative Risk of Cardiovascular Disease among Current Hormone Users as Compared with Women Who Never Used Hormones, According to the Dose of Estrogen, 1980 to 1992.

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The following natural sources of phytoestrogens (estrogen-like compounds) have been identified, but the author is not aware of an effective course of treatment using them.

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HERS was the first large clinical trial specifically designed to evaluate whether estrogen plus progestin therapy reduced the risk for CHD events in postmenopausal women with established coronary disease.

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Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS.

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