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Do endocrine treatments for breast cancer have a negative impact on lipid profiles and cardiovascular risk in postmenopausal women?
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Several factors play a role in determining which side effects are likely (or unlikely) to occur, including the strength of the estrogen, the type of progestin, and the dose of progestin.
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However, in December 2003, a review of the available evidence on the risks and benefits of HRT by the Medicines and Healthcare products Regulatory Agency (MHRA) and the Committee on Safety of Medicines (CSM) in the UK, concluded that the risks of using HRT long-term to prevent osteoporosis in women aged over 50 years exceed the benefits.
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Used in the past for prevention of postpartum breast engorgement; FDA has withdrawn approval of estrogen-containing drugs for this indication, since estrogens have not been shown to be safe for this use.
We also examined the risk of coronary disease according to the current dose of oral conjugated estrogen ( Table 4 Relative Risk of Cardiovascular Disease among Current Hormone Users as Compared with Women Who Never Used Hormones, According to the Dose of Estrogen, 1980 to 1992.
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After 21 days of treatment, test and reference presented practically no differences in terms of their effects on endometrial thickness and vaginal maturation index.
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